Estrogen receptor-alpha variants are associated with lipoprotein size distribution and particle levels in women: the Framingham Heart Study.

doi:10.1016/j.atherosclerosis.2005.06.008

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Article

Estrogen receptor-alpha variants are associated with lipoprotein size distribution and particle levels in women: the Framingham Heart Study.

Atherosclerosis - 1 Mar 2006

Demissie Serkalem, Cupples L Adrienne, Shearman Amanda M, Gruenthal Kristen M, Peter Inga, Schmid Christopher H, Karas Richard H, Housman David E, Mendelsohn Michael E, Ordovas Jose M

Abstract excerpt

Plasma lipid profile is affected by endogenous estrogen levels and hormone replacement therapy (HRT). As plasma lipid concentrations have a significant heritable basis and the effects of both endogenous estrogen and use of HRT are mediated by estrogen receptors, we sought to investigate the relationships between polymorphisms in estrogen receptor-alpha (ESR1) and plasma lipid and lipoprotein concentrations. We...

Topics

Alleles
DNA
Estrogen Receptor alpha
Female
Gene Frequency
Genetic Markers
Haplotypes
Heart Diseases
Humans
Linkage Disequilibrium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lipoproteins, LDL

Magnetic Resonance Spectroscopy

Menopause

Middle Aged

Polymerase Chain Reaction

Polymorphism, Genetic

Source

Open in PubMed

Identifiers

PMID: 16005459
DOI: 10.1016/j.atherosclerosis.2005.06.008

Genes

ESR1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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