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Article

Functional basis for the overlap in ligand interactions and substrate specificities of matrix metalloproteinases-9 and -2.

The Biochemical journal - 15 Nov 2005

Xu Xiaoping, Chen Zhihua, Wang Yao, Yamada Yoshishige, Steffensen Bjorn

Abstract excerpt

The MMPs (matrix metalloproteinases) MMP-9 and -2 each possess a unique CBD (collagen-binding domain) containing three fibronectin type II-like modules. The present experiments investigated whether the contributions to ligand interactions and enzymatic activities by the CBD of MMP-9 (CBD-9) corresponded to those of CBD in MMP-2 (CBD-2). The interactions of recombinant CBD-9 with a series of collagen types and...

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Source

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Identifiers

PMID: 16008524
DOI: 10.1042/BJ20050650
PMCID: PMC1317671

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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