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Matrix Metalloproteinase-2 Contributes to Cancer Cell Migration on Collagen

2005-01-01

Abstract excerpt

Abstract Matrix metalloproteinases (MMP) are central to tissue penetration by cancer cells, as tumors expand and form metastases, but the mechanism by which MMP-2 contributes to cancer cell migration is not well understood. In the present experiments, both a broad-spectrum MMP inhibitor and the isolated collagen binding domain (CBD) from MMP-2 inhibited cell migration on native type I collagen. These results verif...

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Literature Corpus work
84c5453b-2087-5d6f-92cf-0da11921a56b
DOI
10.1158/0008-5472.130.65.1
Open publication

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