Article
Selective modulation of matrix metalloproteinase 9 (MMP-9) functions via exosite inhibition.
The Journal of biological chemistry - 18 Jul 2008
Lauer-Fields Janelle L, Whitehead John K, Li Shunzi, Hammer Robert P, Brew Keith, Fields Gregg B
Abstract excerpt
Unregulated activities of the matrix metalloproteinase (MMP) family have been implicated in primary and metastatic tumor growth, angiogenesis, and pathological degradation of extracellular matrix components, such as collagen and laminin. However, clinical trials with small molecule MMP inhibitors have been largely unsuccessful, with a lack of selectivity considered particularly problematic. Enhanced selectivity...
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