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Article

Screening for RAD51 and BRCA2 BRC repeat mutations in breast and ovarian cancer families.

Cancer letters - 8 May 2006

Rapakko Katrin, Heikkinen Katri, Karppinen Sanna-Maria, Winqvist Robert

Abstract excerpt

Together, germline mutations in the two major susceptibility genes BRCA1 and BRCA2 account for approximately 20-30% and 70-80% of the familial breast and ovarian cancer cases, respectively. This indicates involvement of additional susceptibility genes, perhaps in combination with a polygenic effect. However, it is also possible that part of the mutations disrupting BRCA1 and BRCA2 function still remains to be...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16005565
DOI: 10.1016/j.canlet.2005.05.032

Genes

BRCA2
RAD51
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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