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Article

Functional impairment of telomerase in sublines derived from human lung adenocarcinoma exposed to mild oxidative stress.

Biochemical and biophysical research communications - 26 Aug 2005

Katakura Yoshinori, Yoshizaki Kaichi, Yasuda Tomoharu, Tsunematsu Takahiro, Uehara Norihisa, Miura Takumi, Fujiki Tsukasa, Shirahata Sanetaka

Abstract excerpt

We investigated the effects of a sublethal concentration of H(2)O(2) on cancer cells by using sublines derived from human lung adenocarcinoma cell line A549 cells exposed to 200 microM H(2)O(2). These sublines (AST cells) showed an elongated morphology distinct from the rounded morphology of A549 cells. Notably, AST cells demonstrated telomere shortening despite displaying telomerase activity and expressing human...

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Identifiers

PMID: 16004965
DOI: 10.1016/j.bbrc.2005.06.109

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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