Article
Invariant aphthovirus consensus nucleotide sequence in the transition to error catastrophe.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Oct 2005
González-López Claudia, Gómez-Mariano Gema, Escarmís Cristina, Domingo Esteban
Abstract excerpt
RNA viruses replicate as complex distributions of non-identical but closely related variant genomes termed viral quasispecies. When the error rate during genome replication exceeds a threshold value, the genetic information cannot be maintained and the system enters error catastrophe. This violation of the error threshold results in virus extinction and it is currently being investigated as a new antiviral...
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