Article
Regulation of store‐operated calcium entries and mitochondrial uptake by minidystrophin expression in cultured myotubes
27 Oct 2005
Abstract excerpt
Defective expression of dystrophin in muscle cells is the primary feature of Duchenne muscular dystrophy (DMD), which is accompanied by fiber necrosis and intracellular calcium mishandling. These features led to the hypothesis that dystrophin could control calcium movements. Calcium mishandling in human DMD myotubes is dependent on contraction and/or calcium release activity, suggesting the involvement of...
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