Article
Accumulation of STIM1 is associated with the degenerative muscle fibre phenotype in ALS and other neurogenic atrophies.
Neuropathology and applied neurobiology - 1 Apr 2015
Goswami Anand, Jesse Christofer Marvin, Chandrasekar Akila, Bushuven Eva, Vollrath Jan Tilmann, Dreser Alice, Katona Istvan, Beyer Cordian, Johann Sonja, Feller A C, Grond M, Wagner S, Nikolin Stefan, Troost Dirk, Weis Joachim
Abstract excerpt
AIM: Upon denervation, skeletal muscle fibres initiate complex changes in gene expression. Many of these genes are involved in muscle fibre remodelling and atrophy. Amyotrophic lateral sclerosis (ALS) leads to progressive neurodegeneration and neurogenic muscular atrophy (NMA). Disturbed calcium homeostasis and misfolded protein aggregation both in motor neurones and muscle fibres are key elements of ALS...
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