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Article

A genetic screen for dominant modifiers of a small-wing phenotype in Drosophila melanogaster identifies proteins involved in splicing and translation.

Genetics - 1 Oct 2005

Coelho Carmen M A, Kolevski Benjamin, Walker Cherryl D, Lavagi Irene, Shaw Thomas, Ebert Anselm, Leevers Sally J, Marygold Steven J

Abstract excerpt

Studies in the fly, Drosophila melanogaster, have revealed that several signaling pathways are important for the regulation of growth. Among these, the insulin receptor/phosphoinositide 3-kinase (PI3K) pathway is remarkable in that it affects growth and final size without disturbing pattern formation. We have used a small-wing phenotype, generated by misexpression of kinase-dead PI3K, to screen for novel...

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Share to Crosses, Genetic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Complementation Test

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Share to Polymorphism, Single-Stranded Conformational

Share to Protein Biosynthesis

Share to RNA Splicing

Share to Wings, Animal

Source

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Identifiers

PMID: 15998720
DOI: 10.1534/genetics.105.045021
PMCID: PMC1456774

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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