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Article

The replicative restriction of lymphocytotropic isolates of HIV-1 in macrophages is overcome by TGF-beta.

AIDS research and human retroviruses - 1 Apr 1992

Lazdins J K, Klimkait T, Woods-Cook K, Walker M, Alteri E, Cox D, Cerletti N, Shipman R, Bilbe G, McMaster G

Abstract excerpt

In vitro exposure of human blood monocyte-derived macrophages to T-cell tropic human immunodeficiency virus (HIV) isolates fails to establish a productive viral infection. Several studies have shown that such preferential HIV-1 replication in T cells or in mononuclear phagocytes (HIV tropism) may be determined by distinct viral characteristics. In the present study it was demonstrated that transforming growth...

Topics

Cells, Cultured
HIV-1
Humans
Immunoblotting
Kinetics
Macrophages
Phagocytes
Phenotype
T-Lymphocytes
Transforming Growth Factor beta
Virus Replication

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 1599757
DOI: 10.1089/aid.1992.8.505

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ADA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1599757-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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