Article
Pivotal function for cytoplasmic protein FROUNT in CCR2-mediated monocyte chemotaxis.
Nature immunology - 1 Aug 2005
Terashima Yuya, Onai Nobuyuki, Murai Masako, Enomoto Masahiko, Poonpiriya Vongsakorn, Hamada Tsuyoshi, Motomura Kazushi, Suwa Makiko, Ezaki Taichi, Haga Tatsuya, Kanegasaki Shiro, Matsushima Kouji
Abstract excerpt
Ligation of the chemokine receptor CCR2 on monocytes and macrophages with its ligand CCL2 results in activation of the cascade consisting of phosphatidylinositol-3-OH kinase (PI(3)K), the small G protein Rac and lamellipodium protrusion. We show here that a unique clathrin heavy-chain repeat homology protein, FROUNT, directly bound activated CCR2 and formed clusters at the cell front during chemotaxis....
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