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Article

Effects of dietary intake and genetic factors on hypermethylation of the<i>hMLH1</i>gene promoter in gastric cancer

1 Jan 2005

Abstract excerpt

AIM: Hypermethylation of the promoter of the hMLH1 gene, which plays an important role in mismatch repair during DNA replication, occurs in more than 30% of human gastric cancer tissues. The purpose of this study was to investigate the effects of environmental factors, genetic polymorphisms of major metabolic enzymes, and microsatellite instability on hypermethylation of the promoter of the hMLH1 gene in gastric...

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Identifiers

PMID: 15991278
DOI: 10.3748/wjg.v11.i25.3834

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