Article
DNA methylation in esophageal diseases including cancer: special reference to hMLH1 gene promoter status.
Tumori - 1 Jan 2000
Vasavi Mohan, Ponnala Shivani, Gujjari Kusumanjali, Boddu Prabhakar, Bharatula Ravi Shankar, Prasad Rupender, Ahuja Yog Raj, Hasan Qurratulain
Abstract excerpt
AIMS AND BACKGROUND: Chronic inflammation leading to malignancy in the esophagus may be due to errors in mismatch repair (MMR) genes such as hMLH1. Promoter hypermethylation has been suggested as the main cause of hMLH1 silencing. In this study we assessed hMLH1 promoter hypermethylation in a ran...
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