Article
A cholesteryl ester transfer protein gene mutation and vascular disease in dialysis patients.
Journal of the American Society of Nephrology : JASN - 1 Feb 1999
Kimura H, Gejyo F, Yamaguchi T, Suzuki S, Imura T, Miyazaki R, Arakawa M
Abstract excerpt
Among patients undergoing maintenance hemodialysis, a decreased high-density lipoprotein cholesterol (HDL-C) concentration is among the most common abnormalities of lipid metabolism and apparently is an independent risk factor for vascular disease. A common missense mutation of cholesteryl ester transfer protein gene, D442G (Asp 442 to Gly), increases HDL-C levels through the reduced activity of cholesteryl ester...
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