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Article

Dysregulation of the peroxisome proliferator-activated receptor target genes by XPD mutations.

Molecular and cellular biology - 1 Jul 2005

Compe Emmanuel, Drané Pascal, Laurent Camille, Diderich Karin, Braun Cathy, Hoeijmakers Jan H J, Egly Jean-Marc

Abstract excerpt

Mutations in the XPD subunit of TFIIH give rise to human genetic disorders initially defined as DNA repair syndromes. Nevertheless, xeroderma pigmentosum (XP) group D (XP-D) patients develop clinical features such as hypoplasia of the adipose tissue, implying a putative transcriptional defect. Knowing that peroxisome proliferator-activated receptors (PPARs) are implicated in lipid metabolism, we investigated the...

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Source

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Identifiers

PMID: 15988019
DOI: 10.1128/MCB.25.14.6065-6076.2005
PMCID: PMC1168804

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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