Article
Expression and post-translational modification of human 4-hydroxy-phenylpyruvate dioxygenase.
Cell biology international - 1 Jan 2002
Aarenstrup Lene, Falch Anne Marie, Jakobsen Kirsten K, Neve Søren, Henriksen L Linda Ø, Tommerup Niels, Leffers Henrik, Kristiansen Karsten
Abstract excerpt
4-hydroxyphenylpyruvate dioxygenase (HPD) (EC 1.13.11.27) is a key enzyme involved in tyrosine catabolism. Congenital HPD deficiency is a rare, relatively benign condition known as hereditary type III tyrosinemia. The severe type I tyrosinemia, caused by a deficiency of fumarylacetoacetate hydrolase which functions downstream of HPD in the tyrosine degradation pathway, is often associated with decreased...
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