Article
Application of fluorescent differential display and peroxisome proliferator-activated receptor (PPAR) alpha-null mice to analyze PPAR target genes.
Methods in enzymology - 1 Jan 2002
Lee Susanna Sau-Tuen, Tian Li, Lee Wing-Sum, Cheung Wing-Tai
Abstract excerpt
In conclusion, we have applied the fluorescent differential method and the PPAR alpha-null mouse model for the rapid isolation of expression tags of PPAR alpha target genes that are involved in the action of peroxisome proliferators and in the regulation of lipid homeostasis under energy deprivation. Identification of a wide spectrum of PPAR alpha target genes will provide new insights into the diverse cellular...
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