Article
Selective regulation of vitamin D receptor-responsive genes by TFIIH.
Molecular cell - 22 Oct 2004
Drané Pascal, Compe Emmanuel, Catez Philippe, Chymkowitch Pierre, Egly Jean-Marc
Abstract excerpt
Mutations in the XPD subunit of the transcription/repair factor TFIIH cause the Xeroderma pigmentosum disorder. We show that in some XP-D deficient cells, transactivation by the vitamin D receptor (VDR) is selectively inhibited for a subset of responsive genes, such as CYP24, and that the XPD/R683W mutation prevents VDR recruitment on its promoter. Contrary to other nuclear receptors, VDR, which lacks a...
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