Article
Mutation analysis of the ATR gene in breast and ovarian cancer families.
Breast cancer research : BCR - 1 Jan 2005
Heikkinen Katri, Mansikka Virpi, Karppinen Sanna-Maria, Rapakko Katrin, Winqvist Robert
Abstract excerpt
INTRODUCTION: Mutations in BRCA1, BRCA2, ATM, TP53, CHK2 and PTEN account for only 20-30% of the familial aggregation of breast cancer, which suggests the involvement of additional susceptibility genes. The ATR (ataxia-telangiectasia- and Rad3-related) kinase is essential for the maintenance of genomic integrity. It functions both in parallel and cooperatively with ATM, but whereas ATM is primarily activated by...
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