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Article

Associations of ATR and CHEK1 single nucleotide polymorphisms with breast cancer.

PloS one - 1 Jan 2013

Lin Wei-Yu, Brock Ian W, Connley Dan, Cramp Helen, Tucker Rachel, Slate Jon, Reed Malcolm W R, Balasubramanian Sabapathy P, Cannon-Albright Lisa A, Camp Nicola J, Cox Angela

Abstract excerpt

DNA damage and replication checkpoints mediated by the ATR-CHEK1 pathway are key to the maintenance of genome stability, and both ATR and CHEK1 have been proposed as potential breast cancer susceptibility genes. Many novel variants recently identified by the large resequencing projects have not yet been thoroughly tested in genome-wide association studies for breast cancer susceptibility. We therefore used a...

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Share to Ataxia Telangiectasia Mutated Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genetic Predisposition to Disease

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Share to Polymorphism, Single Nucleotide

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Source

Open in PubMed Open full text

Identifiers

PMID: 23844225
DOI: 10.1371/journal.pone.0068578
PMCID: PMC3700940

Genes

ATR
CHEK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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