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Differential p63 and p53 Expression in Human Keloid Fibroblasts and Hypertrophic Scar Fibroblasts

1 Aug 2007

Abstract excerpt

The p63 gene belongs to the p53 gene family and encodes for sequence-specific transcription factors. p63 has been characterized primarily in the context of epidermis where is implicated in the establishment of keratinocyte cell fate and in maintenance of epithelial self-renewal. DeltaNp63 isoform has been showed to be involved in several kinds of human tumors of epidermal origin, even nonmalignant, for the...

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PMID: 17688405
DOI: 10.1089/dna.2007.0591

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