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Interleukin 6 and STAT 3 regulate p63 isoform expression in keratinocytes during regeneration

14 Nov 2015

Abstract excerpt

Epidermal stem cells express several transcriptional modulators required to maintain their undifferentiated and slow-cycling characteristics. One of these transcriptional modulators is p63, the oldest conserved homolog of the tumor suppressor, p53. p63 activity is vital to skin development, homeostasis and wound healing. Regardless of genetic background, p63-null mice have no epidermis or epithelial appendages,...

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PMID: 26566817
DOI: 10.1111/exd.12896

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