Article
Chromosome anomalies detected by interphase fluorescence in situ hybridization: correlation with significant biological features of B-cell chronic lymphocytic leukaemia.
British journal of haematology - 1 Apr 2003
Dewald Gordon W, Brockman Stephanie R, Paternoster Sarah F, Bone Nancy D, O'Fallon Judith R, Allmer Cristine, James Charles D, Jelinek Diane F, Tschumper Renee C, Hanson Curtis A, Pruthi Rajiv K, Witzig Thomas E, Call Timothy G, Kay Neil E
Abstract excerpt
Fluorescence in situ hybridization (FISH) was used to detect 6q-, 11q-, +12, 13q-, 17p- and translocations involving 14q32 in interphase nuclei from blood and/or bone marrow from 113 patients with B-cell chronic lymphocytic leukaemia (B-CLL). A total of 87 patients (77%) had a FISH anomaly: 13q- x 1 was most frequent (64%) followed by 13q- x 2 (28%), +12 (25%), 11q- (15%), 17p- (8%) and 6q- (0%). FISH results for...
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