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Article

G alpha12 interaction with alphaSNAP induces VE-cadherin localization at endothelial junctions and regulates barrier function.

The Journal of biological chemistry - 26 Aug 2005

Andreeva Alexandra V, Kutuzov Mikhail A, Vaiskunaite Rita, Profirovic Jasmina, Meigs Thomas E, Predescu Sanda, Malik Asrar B, Voyno-Yasenetskaya Tatyana

Abstract excerpt

The involvement of heterotrimeric G proteins in the regulation of adherens junction function is unclear. We identified alphaSNAP as an interactive partner of G alpha12 using yeast two-hybrid screening. Glutathione S-transferase pull-down assays showed the selective interaction of alphaSNAP with G alpha12 in COS-7 as well as in human umbilical vein endothelial cells. Using domain swapping experiments, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to GTP-Binding Protein alpha Subunits, G12-G13

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Identifiers

PMID: 15980433
DOI: 10.1074/jbc.M502844200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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