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Article

Maturation and Dispersal of B‐Cell Clones during T Cell‐Dependent Antibody Responses

1 Apr 1992

Abstract excerpt

Germinal centers develop in follicles during TD antibody responses in the first 3 wk following each immunization. In primary responses to protein-based antigens, T-cell help is limiting, follicles develop towards the end of the 1st wk from immunization and the size of the follicular response in relatively small. When T-cell help is provided the primary B-cell response in follicles is much larger, B cells start to...

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Identifiers

PMID: 1597318
DOI: 10.1111/j.1600-065x.1992.tb00635.x

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