Article
Anticipation in familial pancreatic cancer.
Gut - 1 Feb 2006
McFaul C D, Greenhalf W, Earl J, Howes N, Neoptolemos J P, Kress R, Sina-Frey M, Rieder H, Hahn S, Bartsch D K
Abstract excerpt
BACKGROUND: Previous studies of anticipation in familial pancreatic cancer have been small and subject to ascertainment bias. Our aim was to determine evidence for anticipation in a large number of European families. PATIENTS AND METHODS: A total of 1223 individuals at risk from 106 families (264 affected individuals) were investigated. Generation G3 was defined as the latest generation that included any...
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