Article
Clues For Genetic Anticipation In Multiple Endocrine Neoplasia Type 1.
The Journal of clinical endocrinology and metabolism - 1 Jul 2020
van den Broek Medard F M, van Nesselrooij Bernadette P M, Pieterman Carolina R C, Verrijn Stuart Annemarie A, van de Ven Annenienke C, de Herder Wouter W, Dekkers Olaf M, Drent Madeleine L, Havekes Bas, Kerstens Michiel N, Bisschop Peter H, Valk Gerlof D
Abstract excerpt
CONTEXT: Multiple endocrine neoplasia type 1 (MEN1) is a rare autosomal dominant hereditary disease caused by the loss of function of the MEN1 gene, a tumor-suppressor gene that encodes the protein menin. It is characterized by the occurrence of primary hyperparathyroidism (pHPT), duodenopancreatic neuroendocrine tumors (dpNET), pituitary tumors (PIT), adrenal adenomas, and bronchopulmonary (bp-NET), thymic, and...
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