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Modulation of the Cell Growth Regulator mTOR by Epstein-Barr Virus-Encoded LMP2A

12 Apr 2005

Abstract excerpt

Control of translation initiation is one means by which cells regulate growth and proliferation, with components of the protein-synthesizing machinery having oncogenic potential. Expression of latency protein LMP2A by the human tumor virus Epstein-Barr virus (EBV) activates phosphatidylinositol 3-kinase/Akt located upstream of an essential mediator of growth signals, mTOR (mammalian target of rapamycin). We show...

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PMID: 15827164
DOI: 10.1128/jvi.79.9.5499-5506.2005

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