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Article

Real-time RNA profiling within a single bacterium.

Proceedings of the National Academy of Sciences of the United States of America - 28 Jun 2005

Le Thuc T, Harlepp Sébastien, Guet Calin C, Dittmar Kimberly, Emonet Thierry, Pan Tao, Cluzel Philippe

Abstract excerpt

Characterizing the dynamics of specific RNA levels requires real-time RNA profiling in a single cell. We show that the combination of a synthetic modular genetic system with fluorescence correlation spectroscopy allows us to directly measure in real time the activity of any specific promoter in prokaryotes. Using a simple inducible gene expression system, we found that induced RNA levels within a single bacterium...

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Identifiers

PMID: 15967986
DOI: 10.1073/pnas.0503311102
PMCID: PMC1166617

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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