Article
Genomic convergence to identify candidate genes for Parkinson disease: SAGE analysis of the substantia nigra.
Movement disorders : official journal of the Movement Disorder Society - 1 Oct 2005
Noureddine Maher A, Li Yi-Ju, van der Walt Joelle M, Walters Robert, Jewett Rita M, Xu Hong, Wang Tianyuan, Walter Jeffrey W, Scott Burton L, Hulette Christine, Schmechel Don, Stenger Judith E, Dietrich Fred, Vance Jeffery M, Hauser Michael A
Abstract excerpt
Genomic convergence is a multistep approach that combines gene expression with genomic linkage to identify and prioritize susceptibility genes for complex disease. As a first step, we previously performed linkage analysis on 174 multiplex Parkinson's disease (PD) families, identifying five peaks for PD risk and two for genes affecting age at onset (AAO) in PD [Hauser et al., Hum Mol Genet 2003;12:671-677]. We...
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