Article
Genomic convergence: identifying candidate genes for Parkinson's disease by combining serial analysis of gene expression and genetic linkage.
Human molecular genetics - 15 Mar 2003
Hauser Michael A, Li Yi-Ju, Takeuchi Satoshi, Walters Robert, Noureddine Maher, Maready Melinda, Darden Tiffany, Hulette Christine, Martin Eden, Hauser Elizabeth, Xu Hong, Schmechel Don, Stenger Judith E, Dietrich Fred, Vance Jeffery
Abstract excerpt
We present a multifactorial, multistep approach called genomic convergence that combines gene expression with genomic linkage analysis to identify and prioritize candidate susceptibility genes for Parkinson's disease (PD). To initiate this process, we used serial analysis of gene expression (SAGE) to identify genes expressed in two normal substantia nigras (SN) and adjacent midbrain tissue. This identified over...
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