Article
Ozz-E3, a muscle-specific ubiquitin ligase, regulates beta-catenin degradation during myogenesis.
Developmental cell - 1 Feb 2004
Nastasi Tommaso, Bongiovanni Antonella, Campos Yvan, Mann Linda, Toy James N, Bostrom Jake, Rottier Robbert, Hahn Christopher, Conaway Joan Weliky, Harris A John, D'Azzo Alessandra
Abstract excerpt
The identities of the ubiquitin-ligases active during myogenesis are largely unknown. Here we describe a RING-type E3 ligase complex specified by the adaptor protein, Ozz, a novel SOCS protein that is developmentally regulated and expressed exclusively in striated muscle. In mice, the absence of...
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