Article
Ozz-E3, a muscle-specific ubiquitin ligase, regulates beta-catenin degradation during myogenesis.
Developmental cell - 1 Feb 2004
Nastasi Tommaso, Bongiovanni Antonella, Campos Yvan, Mann Linda, Toy James N, Bostrom Jake, Rottier Robbert, Hahn Christopher, Conaway Joan Weliky, Harris A John, D'Azzo Alessandra
Abstract excerpt
The identities of the ubiquitin-ligases active during myogenesis are largely unknown. Here we describe a RING-type E3 ligase complex specified by the adaptor protein, Ozz, a novel SOCS protein that is developmentally regulated and expressed exclusively in striated muscle. In mice, the absence of Ozz results in overt maturation defects of the sarcomeric apparatus. We identified beta-catenin as one of the target...
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