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Article

Repeated ovarian stimulations induce oxidative damage and mitochondrial DNA mutations in mouse ovaries.

Annals of the New York Academy of Sciences - 1 May 2005

Chao Hsiang-Tai, Lee Shu-Yu, Lee Horng-Mo, Liao Tien-Ling, Wei Yau-Huei, Kao Shu-Huei

Abstract excerpt

Superovulation by injection of exogenous gonadotropin is the elementary method to produce in vivo-derived embryos for embryo transfer in women. Increased oocyte aneuploidy, embryo mortality, fetal growth retardation, and congenital abnormalities have been studied at higher-dose stimulations. Ovarian and oocyte biological aging possibly may have adverse implications for human oocyte competence with repeated...

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PMID: 15965057
DOI: 10.1196/annals.1338.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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