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A highly epothilone B-resistant A549 cell line with mutations in tubulin that confer drug dependence.

Molecular cancer therapeutics - 1 Jun 2005

Yang Chia-Ping Huang, Verdier-Pinard Pascal, Wang Fang, Lippaine-Horvath Eva, He Lifeng, Li Dansu, Höfle Gerhard, Ojima Iwao, Orr George A, Horwitz Susan Band

Abstract excerpt

A 95-fold epothilone B (EpoB)-resistant, but not dependent, A549 human lung carcinoma cell line, A549.EpoB40 (EpoB40), has a Gln to Glu mutation at residue 292 that is situated near the M-loop of betaI-tubulin. Further selection of this cell line with higher concentrations of EpoB produced A549.EpoB480 (EpoB480), which is approximately 900-fold resistant to EpoB. This cell line, like EpoB40, exhibits...

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PMID: 15956256
DOI: 10.1158/1535-7163.MCT-05-0024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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