Article
Nephrotic syndrome in the first year of life: two thirds of cases are caused by mutations in 4 genes (NPHS1, NPHS2, WT1, and LAMB2).
Pediatrics - 1 Apr 2007
Hinkes Bernward G, Mucha Bettina, Vlangos Christopher N, Gbadegesin Rasheed, Liu Jinhong, Hasselbacher Katrin, Hangan Daniela, Ozaltin Fatih, Zenker Martin, Hildebrandt Friedhelm
Abstract excerpt
OBJECTIVES: Mutations in each of the NPHS1, NPHS2, WT1, and LAMB2 genes have been implicated in nephrotic syndrome, manifesting in the first year of life. The relative frequency of causative mutations in these genes in children with nephrotic syndrome manifesting in the first year of life is unknown. Therefore, we analyzed all 4 of the genes jointly in a large European cohort of 89 children from 80 families with...
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