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Article

Insomnia improvement during antidepressant treatment and CLOCK gene polymorphism.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Aug 2005

Serretti Alessandro, Cusin Cristina, Benedetti Francesco, Mandelli Laura, Pirovano Adele, Zanardi Raffaella, Colombo Cristina, Smeraldi Enrico

Abstract excerpt

Sleep disturbances are commonly observed in mood disorders, and sleep manipulations can influence the clinical status. In the present study, we investigated the possible effect of the 3111 T/C circadian locomotor output cycles kaput (CLOCK) gene polymorphism on insomnia symptomatology during antidepressant treatment. One hundred seventy-eight inpatients were treated with fluvoxamine 300 mg/day (n = 147) or...

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PMID: 15952199
DOI: 10.1002/ajmg.b.30130

Genes

CLOCK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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