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Article

Genetic dissection of psychopathological symptoms: insomnia in mood disorders and CLOCK gene polymorphism.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 15 Aug 2003

Serretti Alessandro, Benedetti Francesco, Mandelli Laura, Lorenzi Cristina, Pirovano Adele, Colombo Cristina, Smeraldi Enrico

Abstract excerpt

We investigated the possible effect of the 3111T/C CLOCK gene polymorphism on sleep disorders in a sample of 620 patients affected by major depressive disorder (MDD) and bipolar disorder (BP). We detected a significantly higher recurrence of initial (P = 0.0001), middle (P = 0.0009), and early (P = 0.0008) insomnia in homozygotes for the C variant and a similar trend concerning decreased need of sleep in BP (P =...

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Source

Identifiers

PMID: 12898572
DOI: 10.1002/ajmg.b.20053

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CLOCK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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