Article
A genetic CLOCK variant associated with cluster headache causing increased mRNA levels.
Cephalalgia : an international journal of headache - 1 Mar 2018
Fourier Carmen, Ran Caroline, Zinnegger Margret, Johansson Anne-Sofie, Sjöstrand Christina, Waldenlind Elisabet, Steinberg Anna, Belin Andrea Carmine
Abstract excerpt
Background Cluster headache is characterized by recurrent unilateral headache attacks of severe intensity. One of the main features in a majority of patients is a striking rhythmicity of attacks. The CLOCK ( Circadian Locomotor Output Cycles Kaput) gene encodes a transcription factor that serves as a basic driving force for circadian rhythm in humans and is therefore particularly interesting as a candidate gene...
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