Article
Research on screening and identification of proteins interacting with ataxin-3.
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics - 1 Jun 2005
Shen Lu, Tang Jian-guang, Tang Bei-sha, Jiang Hong, Zhao Guo-hua, Xia Kun, Zhang Yu-hu, Cai Fang, Tan Li-ming, Pan Qian
Abstract excerpt
OBJECTIVE: This study sought to isolate and identify the proteins that interact with ataxin-3, to confirm the interacted domain, and to provide new clues for exploring the function of ataxin-3 and the pathogenesis of spinocerebellar ataxia type 3 and Machado-Joseph disease (SCA3/MJD). METHODS: Yeast two-hybrid screen (MATCHMAKER GAL4 Two-Hybrid System 3) and regular molecular biologic techniques were undertaken...
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