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Article

Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1.

Cell - 16 May 2003

Chen Hung-Kai, Fernandez-Funez Pedro, Acevedo Summer F, Lam Yung C, Kaytor Michael D, Fernandez Michael H, Aitken Alastair, Skoulakis Efthimios M C, Orr Harry T, Botas Juan, Zoghbi Huda Y

Abstract excerpt

Spinocerebellar ataxia type 1 (SCA1) is one of several neurological disorders caused by a CAG repeat expansion. In SCA1, this expansion produces an abnormally long polyglutamine tract in the protein ataxin-1. Mutant polyglutamine proteins accumulate in neurons, inducing neurodegeneration, but the mechanism underlying this accumulation has been unclear. We have discovered that the 14-3-3 protein, a multifunctional...

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PMID: 12757707
DOI: 10.1016/s0092-8674(03)00349-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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