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[Polyglutamine-expanded ataxin-3 is degraded by autophagy].

Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics - 1 Feb 2010

Xiao Han, Tang Jianguang, Hu Zhiping, Tan Jieqiong, Tang Beisha, Jiang Zheng

Abstract excerpt

OBJECTIVE: To investigate the role of autophagy on the pathogenesis of spinocerebellar ataxia 3/Machado-Joseph disease (SCA3/MJD). METHODS: HEK293 cells expressing polyglutamine-expanded ataxin-3 were used as cell model for SCA3/MJD. The level of polyglutamine-expanded ataxin-3 was detected after cells were treated with different inhibitors or inducer of autophagy. RESULTS: Inhibition of autophagy increased...

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PMID: 20140862
DOI: 10.3760/cma.j.issn.1003-9406.2010.01.005

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