Article
Characterization of vestibular dysfunction in the mouse model for Usher syndrome 1F.
Journal of the Association for Research in Otolaryngology : JARO - 1 Jun 2005
Alagramam Kumar N, Stahl John S, Jones Sherri M, Pawlowski Karen S, Wright Charles G
Abstract excerpt
The deaf-circling Ames waltzer (av) mouse harbors a mutation in the protocadherin 15 (Pcdh15) gene and is a model for inner ear defects associated with Usher syndrome type 1F. Earlier studies showed altered cochlear hair cell morphology in young av mice. In contrast, no structural abnormality consistent with significant vestibular dysfunction in young av mice was observed. Light and scanning electron microscopic...
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