New algorithms for Luria-Delbrück fluctuation analysis.

Abstract excerpt

Fluctuation analysis is the most widely used approach in estimating microbial mutation rates. Development of methods for point and interval estimation of mutation rates has long been hampered by lack of closed form expressions for the probability mass function of the number of mutants in a parallel culture. This paper uses sequence convolution to derive exact algorithms for computing the score function and...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Algorithms
• Share to Computer Simulation
• Share to Escherichia coli