Article
Antifungal activity of synthetic peptides derived from Impatiens balsamina antimicrobial peptides Ib-AMP1 and Ib-AMP4.
Peptides - 1 Jul 2005
Thevissen Karin, François Isabelle E J A, Sijtsma Lolke, van Amerongen Aart, Schaaper Wim M M, Meloen Rob, Posthuma-Trumpie Truus, Broekaert Willem F, Cammue Bruno P A
Abstract excerpt
Seeds of Impatiens balsamina contain a set of related antimicrobial peptides (Ib-AMPs). We have produced a synthetic variant of Ib-AMP1, oxidized to the bicyclic native conformation, which was fully active on yeast and fungal strains; and four linear 20-mer Ib-AMP variants, including two all-D forms. We show that the all-D variants are as active on yeast and fungal strains as native peptides. In addition, fungal...
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