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Article

Identification of novel Amurin-2 variants from the skin secretion of Rana amurensis, and the design of cationicity-enhanced analogues.

Biochemical and biophysical research communications - 18 Mar 2018

Zhang Luyao, Chen Xiaoling, Zhang Ying, Ma Chengbang, Xi Xinping, Wang Lei, Zhou Mei, Burrows James F, Chen Tianbao

Abstract excerpt

Rana amurensis is important in Chinese medicine as its skin secretions contain abundant bioactive peptides. Here, we have identified the antimicrobial peptide Amurin-2 and three highly-conserved variants, Amurin-2a, Amurin-2b and Amurin-2c through a combination of molecular cloning and MS/MS fragmentation sequencing. Synthetic replicates of these peptides demonstrate potent antimicrobial activity against...

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Identifiers

PMID: 29366784
DOI: 10.1016/j.bbrc.2018.01.124

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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