Article
In vitro chemoenzymatic and in vivo biocatalytic syntheses of new beauvericin analogues.
Chemical communications (Cambridge, England) - 7 Jun 2012
Matthes Diana, Richter Lennart, Müller Jane, Denisiuk Alexander, Feifel Sven C, Xu Yuquan, Espinosa-Artiles Patricia, Süssmuth Roderich D, Molnár István
Abstract excerpt
New beauvericins have been synthesized using the nonribosomal peptide synthetase BbBEAS from the entomopathogenic fungus Beauveria bassiana. Chemical diversity was generated by in vitro chemoenzymatic and in vivo whole cell biocatalytic syntheses using either a B. bassiana mutant or an E. coli strain expressing the bbBeas gene.
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