Mating-type-specific and nonspecific PAK kinases play shared and divergent roles in Cryptococcus neoformans.

doi:10.1128/EC.1.2.257-272.2002

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Mating-type-specific and nonspecific PAK kinases play shared and divergent roles in Cryptococcus neoformans.

Eukaryotic cell - 1 Apr 2002

Wang Ping, Nichols Connie B, Lengeler Klaus B, Cardenas Maria E, Cox Gary M, Perfect John R, Heitman Joseph

Abstract excerpt

Cryptococcus neoformans is an opportunistic fungal pathogen with a defined sexual cycle involving fusion of haploid MATalpha and MATa cells. Virulence has been linked to the mating type, and MATalpha cells are more virulent than congenic MATa cells. To study the link between the mating type and virulence, we functionally analyzed three genes encoding homologs of the p21-activated protein kinase family:...

Topics

Alleles
Amino Acid Sequence
Animals
Cell Division
Cryptococcosis
Cryptococcus neoformans
Female
Fungal Proteins
Haploidy
MAP Kinase Signaling System
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Models, Genetic

Molecular Sequence Data

Mutation

Protein Kinases

Protein Serine-Threonine Kinases

Rabbits

Source

Open in PubMed Open full text

Identifiers

PMID: 12455960
DOI: 10.1128/EC.1.2.257-272.2002
PMCID: PMC118036

Genes

PAK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Mating-type-specific and nonspecific PAK kinases play shared and divergent roles in Cryptococcus neoformans.PMID 12455960Read ↗

PAK Kinases Ste20 and Pak1 Govern Cell Polarity at Different Stages of Mating inCryptococcus neoformansSemantic proximity Read ↗

Identification of the MATa mating-type locus of <i>Cryptococcus neoformans</i> reveals a serotype A MATa strain thought to have been extinctSemantic proximity Read ↗

The STE12α Homolog Is Required for Haploid Filamentation But Largely Dispensable for Mating and Virulence in Cryptococcus neoformansSemantic proximity Read ↗

The Cryptococcus neoformans STE12alpha gene: a putative Saccharomyces cerevisiae STE12 homologue that is mating type specific.Semantic proximity Read ↗

A homolog of Ste6, the a-factor transporter in Saccharomyces cerevisiae, is required for mating but not for monokaryotic fruiting in Cryptococcus neoformans.Semantic proximity Read ↗

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The Cryptococcus neoformans STE11α gene is similar to other fungal mitogen‐activated protein kinase kinase kinase (MAPKKK) genes but is mating type specificSemantic proximity Read ↗

Cyclic AMP-dependent protein kinase catalytic subunits have divergent roles in virulence factor production in two varieties of the fungal pathogen Cryptococcus neoformans.Semantic proximity Read ↗

Unraveling the cryptic functions of mitogen-activated protein kinases Cpk2 and Mpk2 in Cryptococcus neoformansSemantic proximity Read ↗

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