Article
Heteroplasmic segregation associated with trisomy-9 in cultured human cells.
Somatic cell and molecular genetics - 1 Nov 1999
Lehtinen S K, Spelbrink J N, Jacobs H T
Abstract excerpt
In cybrid cells carrying the mitochondrial A3243G MELAS mutation, which were also heteroplasmic for the G12300A suppressor mutation, we observed a transient episode of heteroplasmic instability, resulting in a wide diversification in G12300A heteroplasmy levels and a shift in the average heteroplasmy level from 11 to 29%. These cells were found to be trisomic for chromosome 9, whereas a minority of cells that...
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