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Article

Unexpected mitochondrial matrix localization of Parkinson's disease-related DJ-1 mutants but not wild-type DJ-1.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Jul 2016

Kojima Waka, Kujuro Yuki, Okatsu Kei, Bruno Queliconi, Koyano Fumika, Kimura Mayumi, Yamano Koji, Tanaka Keiji, Matsuda Noriyuki

Abstract excerpt

DJ-1 has been identified as a gene responsible for recessive familial Parkinson's disease (familial Parkinsonism), which is caused by a mutation in the PARK7 locus. Consistent with the inferred correlation between Parkinson's disease and mitochondrial impairment, mitochondrial localization of DJ-1 and its implied role in mitochondrial quality control have been reported. However, the mechanism by which DJ-1...

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Share to PARK7 gene
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27270837
DOI: 10.1111/gtc.12382

Genes

PARK7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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